Related Experiment Video
Updated: Feb 21, 2026
The Combination of Transcranial Alternating Current Stimulation and Electroencephalogram
Published on: October 10, 2025
After-effects of transcranial alternating current stimulation on evoked delta and theta power
Miles Wischnewski1, Dennis J L G Schutter1
1Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands.
Objective:
Phase synchronization is suggested to be among the mechanisms that can explain the effects of transcranial alternating current stimulation (tACS). However, little is known about the effects of tACS on event-related oscillatory activity. Therefore the objective was to investigate frequency-related effects of frontal tACS on event-related oscillatory power.
Methods:
In a double blind randomized controlled cross-over design, twenty-four participants received 12min of delta (2.5Hz), theta tACS (5Hz) and sham tACS at an intensity of 1mA peak-to-peak. Event-related delta- and theta-related oscillatory activity was recorded to reward- and punishment-related feedback signals.
Results:
Delta tACS decreased feedback-related oscillatory power in the 1.5 and 3.5Hz frequency range. This effect was driven by power changes below the tACS frequency stimulation.
Conclusion:
Exogenous field potentials can attenuate event-related oscillatory activity in a rhythm slightly below the stimulation frequency. Our findings suggest an interaction between tACS and event-related rhythmic activity that extends beyond phase synchronization.
Significance:
These findings add novel insights into the mechanisms of tACS after-effects.
