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Preoperative thrombocytosis as a prognostic factor in endometrioid-type endometrial carcinoma
Ahmed Abu-Zaid, Mohannad Alsabban, Mohammed Abuzaid
1Correspondence: Dr. Ismail A. Al-Badawi Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Centre, MBC 52, P.O. Box 3354, Riyadh 11211, Saudi Arabia ibadawi@kfshrc.edu.sa, i_albadawi@yahoo.com, ORCID: http://orcid.org/0000- 0001-5775-9702.
Background:
The impact of preoperative thrombocytosis as a prognostic factor in endometrial carcinoma (EC) remains uncertain and has never been examined in Saudi Arabia.
Objectives:
To determine the prevalence of preoperative thrombocytosis (platelet count > 400 000/ μL), and its prognostic significance for clinicopathological factors and survival in Saudi patients with endometrioid-type EC.
Design:
A retrospective cross-sectional study from January 2010 to December 2013.
Setting:
A referral tertiary healthcare institute.
Patients And Methods:
Patients who underwent staging surgery for primary endometrioid-type EC were retrospectively analyzed for perioperative details: age, preoperative platelet count, International Federation of Gynecology and Obstetrics (FIGO) stage, endometrioid grade, recurrence, disease-free survival (DFS) and overall survival (OS). Survival analysis was conducted using Kaplan-Meier estimates and a Cox proportional hazards model.
Main Outcome Measures:
Prevalence of preoperative thrombocytosis, DFS and OS.
Results:
In 162 patients who met inclusion criteria, the frequency of preoperative thrombocytosis was 8.6% (n=14). Patients with advanced FIGO disease (stages III-IV) and recurrence had significantly higher mean preoperative platelet counts than patients with early FIGO disease (stages I-II) and no recurrence (P=.0080 and P=.0063, respectively). Patients with thrombocytosis had statistically significant higher rates of advanced FIGO stages III-IV disease, unfavorable grades II-III endometrioid histology and recurrence than patients with preoperative platelet counts.
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