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Updated: Feb 21, 2026
09:07
Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
Published on: May 27, 2015
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Mastocytosis in Children
Nicholas Klaiber1, Santhosh Kumar1, Anne-Marie Irani2
1Department of Pediatrics, Division of Allergy and Immunology, Virginia Commonwealth University Health Systems, 1000 E Broad Street, Richmond, VA, 23219, USA.
Current Allergy and Asthma Reports
|October 9, 2017
Summary
Pediatric mastocytosis typically presents as skin lesions with a good prognosis and often resolves by adolescence. However, systemic mastocytosis is more severe and may continue into adulthood.
Area of Science:
- Pediatric Hematology
- Dermatology
- Immunology
Background:
- Mastocytosis is a rare disorder characterized by the abnormal proliferation of mast cells.
- Understanding its varied presentations and natural history in children is crucial for effective management.
Purpose of the Study:
- To review the current knowledge on pediatric mastocytosis, including its pathogenesis, clinical features, diagnosis, and treatment.
- To elucidate the natural history and prognosis of childhood mastocytosis.
Main Methods:
- Comprehensive literature review of pediatric mastocytosis.
- Analysis of pathogenesis, clinical manifestations, diagnostic approaches, and therapeutic strategies.
- Evaluation of disease progression and long-term outcomes.
Main Results:
- Pediatric mastocytosis commonly manifests as cutaneous lesions with a favorable prognosis and frequent spontaneous remission by adolescence.
- Systemic mastocytosis involving organ systems is a rarer, more severe form with a tendency to persist into adulthood.
- Emerging concepts like mast cell activation syndrome are also considered.
Conclusions:
- Early identification and appropriate management are key for pediatric mastocytosis.
- Distinguishing between cutaneous and systemic forms is vital for predicting disease course and prognosis.
- Further research into mast cell activation syndrome may offer new therapeutic avenues.
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