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Updated: Feb 21, 2026

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro
Published on: November 26, 2018
[Mechanism of migration and release of high mobility group box-1]
Xin Zhao1, Ben Lü1, Erhua Wang2
1Department of Hematology, Third Xiangya Hospital, Central South University, Changsha 410013; Laboratory of Medical Genetics, Central South University, Changsha 410078, China.
Abstract:
High mobility group box-1 (HMGB1) is an evolutionarily conserved protein, which widely exists in mammals. HMGB1 contains the nucleus localization sequences. Intracellular and extracellular HMGB1 shows different biological functions. Extracellular HMGB1 is closely related to sepsis, cancer, rheumatoid immune, atherosclerosis, ischemia-reperfusion injury and so on. The mobilization of HMGB1 from the nucleus to the cytoplasm and subsequent release involves the processes of post-translation modification, active secretion and nuclear localization.
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