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Updated: Feb 21, 2026
11:02
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
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Metabolomics and Heart Diseases: From Basic to Clinical Approach
Ignasi Barba1,2, Mireia Andrés1, David Garcia-Dorado1,2
1Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain.
Current Medicinal Chemistry
|October 10, 2017
Summary
Metabolomics, the study of small molecules, is increasingly applied to cardiovascular diseases. While promising for diagnosis and treatment, it
Area of Science:
- Metabolomics
- Cardiovascular Medicine
- Biomarker Discovery
Background:
- Metabolomics has grown significantly over 15 years, driven by analytical and statistical advances.
- Cardiovascular diseases are a major focus due to their impact and the role of metabolic alterations.
- Current applications span risk stratification, myocardial infarction, and heart failure, yet clinical integration is pending.
Purpose of the Study:
- To introduce the field of metabolomics.
- To review existing metabolomic research in cardiovascular diseases.
- To highlight the potential for clinical translation.
Main Methods:
- Literature review of metabolomic studies in cardiovascular diseases.
- Analysis of the current state and future directions of metabolomics in cardiology.
Main Results:
- Numerous proof-of-concept studies demonstrate metabolomics' utility in cardiovascular disease diagnosis, prognosis, and treatment evaluation.
- Large-scale phenome centers are emerging to validate clinical applicability.
- Opportunities exist for smaller centers to address specific clinical questions and rare pathologies.
Conclusions:
- The cardiovascular field has pioneered metabolomics applications.
- Clinical translation of metabolomics in cardiology is anticipated in the near future.
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