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Utilization patterns of systemic corticosteroid use for chronic rhinosinusitis.

Stacey T Gray1,2, Katie M Phillips1,2, Lloyd P Hoehle1,2

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Acta Oto-Laryngologica
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Summary

Previous oral corticosteroid use for chronic rhinosinusitis (CRS) is linked to specific symptom severity. These symptoms differ based on the presence of nasal polyps, impacting treatment decisions.

Keywords:
Chronic rhinosinusitisSNOT-22emotional symptomsfacial painnasal symptomsoral corticosteroidsotologic symptomspolypsprincipal component analysissleep

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Area of Science:

  • Otolaryngology
  • Rhinology
  • Pharmacology

Background:

  • Chronic rhinosinusitis (CRS) poses a significant burden, often necessitating systemic corticosteroid treatment.
  • Understanding patterns of corticosteroid use is crucial for optimizing patient care and managing CRS effectively.

Purpose of the Study:

  • To investigate the utilization patterns of systemic corticosteroids in patients with CRS.
  • To identify factors associated with the use of oral corticosteroids for CRS management.

Main Methods:

  • A cross-sectional study involving 236 participants diagnosed with CRS.
  • Data collection included demographics, clinical characteristics, and self-reported oral corticosteroid courses in the past year.
  • Symptom severity was assessed using the 22-item Sinonasal Outcome Test (SNOT-22) and its subdomain scores.

Main Results:

  • Nasal polyps and specific SNOT-22 subdomain scores (sleep, nasal, otologic/facial pain) were associated with oral corticosteroid use.
  • In patients without polyps, prior corticosteroid use correlated with sleep, otologic/facial pain, and nasal symptom severity.
  • In patients with polyps, prior use was primarily associated with nasal symptom severity.

Conclusions:

  • Past oral corticosteroid use in CRS is associated with heightened baseline symptom severity.
  • The specific symptoms linked to corticosteroid use vary depending on the presence or absence of nasal polyps.