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Published on: August 17, 2022
Obstructive sleep apnoea: from respiratory events to coronary microvascular dysfunction.
Sofia Morra1,2, François Roubille1
1a Department of Cardiology , University Hospital of Montpellier , Montpellier , France.
Obstructive sleep apnoea (OSA) is linked to coronary artery disease (CAD). This study suggests coronary microvascular dysfunction (CMD) during breathing events may explain heart issues in OSA patients.
Area of Science:
- Cardiology
- Sleep Medicine
- Vascular Biology
Background:
- Obstructive sleep apnoea (OSA) is an independent cardiovascular disease risk factor.
- Coronary artery disease (CAD) prevalence is elevated in OSA patients, irrespective of traditional risk factors.
Purpose of the Study:
- Investigate coronary blood flow (CBF) and coronary vascular resistance (CVR) during obstructive events in OSA.
- Explore coronary microvascular dysfunction (CMD) as a mechanism linking OSA to ischaemic heart disease (IHD).
Main Methods:
- Analysis of coronary haemodynamics during obstructive respiratory events.
- Assessment of potential mechanisms for IHD in OSA patients.
Main Results:
- Limited evidence currently exists on CBF and CVR abnormalities during OSA events.
- Coronary microvascular dysfunction (CMD) is proposed as a potential pathway.
Conclusions:
- OSA may contribute to IHD through mechanisms involving CMD.
- Further research is needed to elucidate the relationship between OSA, CBF, CVR, and IHD.
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