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Testosterone replacement therapy and cardiovascular events

Alp Burak Çatakoğlu1, Muammer Kendirci

  • 1Department of Cardiology, İstinye University Faculty of Medicine, İstanbul, Turkey. alpburak@hotmail.com.

Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir
|October 10, 2017
PubMed

Insights

Low testosterone levels and hypogonadism are linked to cardiovascular disease. This review examines the conflicting evidence on testosterone replacement therapy (TRT) safety in older men and those with heart conditions.

Area of Science:

  • Endocrinology
  • Cardiology
  • Geriatrics

Background:

  • Low testosterone levels and hypogonadism are increasingly recognized as potential contributors to cardiovascular disease (CVD).
  • Factors such as aging, obesity, and chronic health conditions are associated with both hypogonadism and CVD.
  • Testosterone replacement therapy (TRT) is frequently prescribed for men with diagnosed hypogonadism.

Purpose of the Study:

  • To review the existing literature regarding the cardiovascular safety of testosterone replacement therapy (TRT).
  • To evaluate the potential risks associated with TRT, particularly in vulnerable patient populations.

Main Methods:

  • A comprehensive literature review was conducted.
  • Studies examining the association between TRT and adverse cardiovascular events were analyzed.

Main Results:

  • Current evidence on the cardiovascular safety of TRT remains contradictory.
  • Older men and individuals with pre-existing cardiovascular conditions may face increased risks when undergoing TRT.

Conclusions:

  • The cardiovascular implications of TRT require careful consideration.
  • Further research is needed to clarify the risks and benefits of TRT in diverse patient groups, especially those susceptible to cardiovascular events.

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