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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
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Masaaki Miyo1, Ichiro Takemasa, Hiroyuki Ishihara

  • 11Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan 2Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan 3Department of Mathematical Health Science, Osaka University Graduate School of Medicine, Suita, Japan.

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No abstract available in PubMed .

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