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Area of Science:

  • Agrochemistry
  • Medicinal Chemistry
  • Computational Chemistry

Background:

  • Scaffold hopping is crucial for lead discovery and optimization in drug and agrochemical development.
  • It addresses challenges like toxicity, intellectual property, and suboptimal potency or stability.
  • Diverse scaffold hopping strategies are employed to create isofunctional molecules with novel backbones.

Purpose of the Study:

  • To explain the application of scaffold hopping tools in crop protection research.
  • To illustrate successful scaffold hopping applications with real-world examples in agrochemistry.
  • To compare scaffold hopping in agrochemistry with its use in medicinal drug discovery.

Main Methods:

  • Isosteric ring replacement (e.g., 1,3 nitrogen shift, cyclic imine-amide isosterism).
  • Ring opening and ring closure techniques.
  • Functional group isosterism, functional group reversion, chain modifications, and natural product-derived scaffolds.

Main Results:

  • Scaffold hopping has become integral to innovation and optimization in crop protection.
  • Successful applications demonstrate its value in developing new agrochemicals.
  • The study provides case studies of successful scaffold hopping in agrochemistry.

Conclusions:

  • Scaffold hopping is a versatile and effective approach in agrochemical research and development.
  • Understanding its methodologies and applications can accelerate the discovery of novel crop protection agents.
  • The principles of scaffold hopping in agrochemistry share similarities and differences with medicinal chemistry.