Ocular Autoimmune Systemic Inflammatory Infectious Study - Report 3: Posterior and Panuveitis

Area of Science:

• Ophthalmology
• Immunology
• Infectious Diseases

Background:

• Posterior uveitis and panuveitis are complex ocular inflammatory conditions.
• Etiological patterns can vary significantly across different geographic regions and healthcare settings.
• Understanding these patterns is crucial for effective clinical management.

Purpose of the Study:

• To characterize the etiological patterns of posterior uveitis and panuveitis.
• To report on the visual outcomes and complications associated with these conditions.
• To provide data from a tertiary referral center in Singapore.

Main Methods:

• Retrospective analysis of 334 new cases of posterior and panuveitis.
• Data sourced from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database.
• Descriptive analysis of etiological distribution, visual outcomes, and complications.

Main Results:

• Infectious etiologies accounted for 48.5% of cases, non-infectious for 43.1%, and 8.4% were idiopathic.
• Bilateral disease was more frequently associated with non-infectious etiologies (50.9%).
• Common complications included epiretinal membrane in the infectious group and cystoid macular edema in the non-infectious group.

Conclusions:

• The etiological profile of posterior and panuveitis in this Singaporean cohort differs from other reported studies.
• Recognizing demographic associations and variations in etiology is key to improving diagnostic and management strategies.
• Further research into regional variations can enhance patient care for uveitis.