Related Experiment Videos
In-vivo studies with the opioid antagonist, 16-methylcyprenorphine
P J Birch1, A G Hayes, M J Sheehan
1Department of Neuropharmacology, Glaxo Group Research Ltd., Ware, Herts, UK.
The Journal of Pharmacy and Pharmacology
|March 1, 1988
Abstract:
The effect of the opioid antagonist, 16-methylcyprenorphine (RX8008M), on the antinociceptive action of the mu-selective agonist, morphine, and the kappa-selective agonist, U50488H, has been investigated in the mouse abdominal constriction test. RX8008M produced a dose-dependent antagonism of the antinociceptive effect of morphine, but did not antagonize the response to U50488H. RX8008M should prove a useful probe for the in-vivo characterization of the receptor selectivity of opioid drugs.