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Inflammaging and the Lung
Elizabeth J Kovacs1, Devin M Boe2, Lisbeth A Boule3
1Division of GI, Trauma and Endocrine Surgery, Department of Surgery, Mucosal Inflammation Program, GILIIP (GI, Liver and Innate Immunity Program), Graduate Program in Immunology, IMAGE (Investigations in Metabolism, Aging, Gender and Exercise), University of Colorado Denver, Anschutz Medical Campus, 12700 East 19th Avenue, Research Complex 2, Mailstop #8620, Aurora, CO 80045, USA.
Abstract:
With the coming of the "silver tsunami," expanding the knowledge about how various intrinsic and extrinsic factors affect the immune system in the elderly is timely and of immediate clinical need. The global population is increasing in age. By the year 2030, more than 20% of the population of the United States will be older than 65 years of age. This article focuses on how advanced age alters the immune systems and how this, in turn, modulates the ability of the aging lung to deal with infectious challenges from the outside world and from within the host.
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