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Related Experiment Videos

Maternal Programming of Body Weight in Syrian Hamsters.

Jeremy M Brozek1, Jill E Schneider1, Erin Rhinehart2

  • 1Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA.

Integrative and Comparative Biology
|October 10, 2017
PubMed
Summary

Maternal food restriction during pregnancy can impact offspring weight, especially in males, even after birth. These effects suggest mild gestational challenges influence postnatal maternal care and offspring development in a sex-specific manner.

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Area of Science:

  • Reproductive biology
  • Developmental biology
  • Nutritional science

Background:

  • Maternal programming influences offspring energy balance, preparing them for the postnatal environment.
  • Mismatched gestational and postnatal environments can lead to adverse programming effects.
  • Most research uses severe food restriction; effects of mild restriction and postgestational carry-over are less understood.

Purpose of the Study:

  • To investigate the independent postgestational effects of maternal food restriction during pregnancy.
  • To determine if mild gestational food restriction impacts offspring characteristics beyond prenatal programming.
  • To examine sex-specific effects of gestational programming and carry-over effects on offspring.

Main Methods:

  • Syrian hamsters were fed either ad libitum or 90% of ad libitum intake during pregnancy.

Related Experiment Videos

  • Litters were cross-fostered at birth to dams with different nutritional statuses during gestation.
  • Offspring body weight, food intake, and food hoarding behavior were assessed.

    • Main Results:

    • Offspring born to ad libitum-fed mothers but nursed by food-restricted foster mothers showed increased postnatal body weight.
    • Carry-over effects of gestational food restriction on offspring body weight were significant in males but not females.
    • Gestational food restriction did not significantly affect adult food hoarding behavior.

    Conclusions:

    • Mild energetic challenges during gestation can have significant postgestational effects on maternal ability.
    • These effects on offspring development are sex-specific, with males being more affected.
    • The study highlights the complex interplay between prenatal and postnatal maternal environments in shaping offspring outcomes.