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Housekeeping and tissue-specific cis-regulatory elements: Recipes for specificity and recipes for activity
Marta Russo1, Gioacchino Natoli1, Serena Ghisletti2
1a Department of Biomedical Sciences , Humanitas University (Hunimed) , Rozzano , Milan , Italy.
Transcription
|October 10, 2017
Abstract:
Cell type-specific and housekeeping enhancers and promoters collectively control the transcriptional output of mammalian cells. Recent data clarify how DNA sequence features on the one hand control functional coupling of promoters with selected enhancers, and on the other impart high level of activity to a broad range of regulatory elements.