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Temporal Patterning in the Drosophila CNS.

Chris Q Doe1

  • 1Institute of Neuroscience, Institute of Molecular Biology, and Howard Hughes Medical Institute (HHMI), University of Oregon, Eugene, Oregon 97403;

Annual Review of Cell and Developmental Biology
|October 10, 2017
PubMed
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Neural progenitors generate diverse CNS cell types using temporal transcription factors (TTFs). Different TTF cascades in Drosophila neuroblasts, influenced by intrinsic and extrinsic cues, drive this crucial developmental process.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Neural progenitors in the central nervous system (CNS) generate diverse cell types.
  • Spatial and temporal patterning are key mechanisms for neural diversity.
  • Temporal transcription factors (TTFs) play a critical role in neurogenesis.

Purpose of the Study:

  • To investigate the role of temporal patterning in generating neural diversity.
  • To understand how different neuroblast lineages utilize TTF cascades.
  • To explore the influence of intrinsic and extrinsic factors on TTF cascades.

Main Methods:

  • Studied Drosophila neuroblasts (embryonic, larval optic lobe, and central brain).
  • Analyzed the sequential expression of TTFs in different neuroblast lineages.
Keywords:
neural diversityneural stem cellneuroblastsubtemporaltemporal identity

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  • Investigated the role of ecdysone hormone signaling in central brain neuroblasts.

    • Main Results:

    • All studied Drosophila neuroblast lineages utilize TTF cascades for diversity.
    • Embryonic and larval optic lobe neuroblasts employ distinct five-factor TTF cascades.
    • Larval central brain neuroblasts exhibit a mid-larval transition regulated by ecdysone.

    Conclusions:

    • Temporal patterning via TTF cascades is a widespread mechanism for generating neural diversity in Drosophila.
    • Lineage-intrinsic TTF cascades and lineage-extrinsic cues like ecdysone regulate neurogenesis.
    • Understanding TTF cascades provides insights into the fundamental processes of CNS development.