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Updated: Feb 21, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
Published on: August 20, 2007
Have we pushed the needle for treatment of Type 1 diabetes?
Nida Naushad1, Ana Luisa Perdigoto1, Jinxiu Rui1
1Departments of Immunobiology and Internal Medicine, Yale University, New Haven, CT, United States.
Abstract:
Studies with immunologics have shown that the natural history of Type 1 diabetes can be modified. These studies have targeted key mediators of the disease and recent analyses, together with studies in preclinical models have identified mechanisms that may be involved in the clinical effects. Several issues remain including specificity of the interventions, adverse effects of the treatments, and duration of their effects. Future studies are likely to include more specific approaches with agents such as cell therapies with selected immune regulatory subsets, antigen specific therapies, and combinations of agents with complementary mechanisms of activity.
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