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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Allergic Reactions: Anaphylaxis01:30

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
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Future Horizons in Allergy.

Michael J Marino1, Amber U Luong1

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, McGovern Medical School at the University of Texas Health Science Center, 6431 Fannin Street, MSB 5.036, Houston, TX 77030, USA.

Otolaryngologic Clinics of North America
|October 11, 2017
PubMed
Summary
This summary is machine-generated.

New diagnostic tools and treatments are advancing allergy care for otolaryngologists. These innovations offer personalized medicine approaches for improved diagnosis and management of allergic and nonallergic conditions.

Keywords:
Allergen immunotherapyAllergic rhinitisAspirin-exacerbated respiratory diseaseImmunoglobulin E

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Area of Science:

  • Otolaryngology
  • Allergy diagnostics
  • Personalized medicine

Background:

  • Allergy diagnosis and management present ongoing challenges for otolaryngologists.
  • Healthcare trends emphasize personalized medicine, requiring advanced diagnostic and therapeutic strategies.

Purpose of the Study:

  • To review recent advances in the diagnosis and management of allergy relevant to otolaryngology.
  • To highlight new technologies and refined techniques for personalized allergy care.

Main Methods:

  • Review of emerging diagnostic technologies: local immunoglobulin, urinary leukotriene E4, lipidomics, microRNA within extracellular vesicles, and optical rhinometry.
  • Examination of novel management strategies: new delivery systems for intranasal steroids and antihistamines, recombinant allergens, immunotherapy delivery advances, and biologics.

Main Results:

  • New diagnostic methods promise enhanced accuracy for allergy and related nonallergic conditions.
  • Advancements in drug delivery, biologics, and immunotherapy offer improved treatment options.
  • These developments support a personalized medicine approach to otolaryngic allergy care.

Conclusions:

  • Otolaryngologists have access to innovative tools for more precise allergy diagnosis.
  • Current management options are expanding with new therapies and delivery systems.
  • These advances collectively improve the ability to diagnose and treat allergy and related diseases effectively.