Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A stepwise neuron model fitting procedure designed for recordings with high spatial resolution: Application to layer

Tuomo Mäki-Marttunen1, Geir Halnes2, Anna Devor3

  • 1NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Simula Research Laboratory, Lysaker, Norway.

Journal of Neuroscience Methods
|October 11, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improved multimodal prediction of progression from MCI to Alzheimer's disease combining genetics with quantitative brain MRI and cognitive measures.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2023
Same author

Childhood Disadvantage Moderates Late Midlife Default Mode Network Cortical Microstructure and Visual Memory Association.

The journals of gerontology. Series A, Biological sciences and medical sciences·2023
Same author

Heritability Estimation of Cognitive Phenotypes in the ABCD Study<sup>®</sup> Using Mixed Models.

Behavior genetics·2023
Same author

Task fMRI paradigms may capture more behaviorally relevant information than resting-state functional connectivity.

NeuroImage·2023
Same author

Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders.

Brain : a journal of neurology·2023
Same author

A Multicompartmental Diffusion Model for Improved Assessment of Whole-Body Diffusion-weighted Imaging Data and Evaluation of Prostate Cancer Bone Metastases.

Radiology. Imaging cancer·2023

This study presents an automated method for creating detailed neuron models that are computationally efficient. These models accurately simulate neuronal biophysics and network dynamics, aiding in the analysis of large-scale neural data.

Area of Science:

  • Computational neuroscience
  • Neuronal modeling
  • Systems neuroscience

Background:

  • Advances in neuronal recording generate high-resolution data.
  • Increasing computational power enables larger neuronal circuit simulations.
  • Accurately modeling neuronal biophysics at subcellular detail while managing simulation costs is challenging.

Purpose of the Study:

  • To develop an automated, stepwise method for fitting neuron models to high-resolution spatial data.
  • To create cost-efficient single-cell and network models that faithfully reproduce neuronal biophysics.

Main Methods:

  • Developed an automated method for fitting neuron models to fine-resolution spatial data (e.g., from voltage-sensitive dyes and Ca2+ imaging).
  • Combined features from existing model-fitting strategies.
Keywords:
Automated fitting methodsBiophysically detailed modelingModel fitting using imaging dataMulti-compartmental neuron modelsParameter peeling

Related Experiment Videos

  • Applied the method to simulated data from layer 5 pyramidal cells (L5PCs).

    • Main Results:

    • Constructed a reduced-morphology L5PC model that accurately reproduces dendritic membrane-potential dynamics.
    • Created a network of reduced-morphology neurons and validated it against a high-resolution L5PC network model.
    • The reduced-morphology model reliably predicts the behavior of full-morphology models.

    Conclusions:

    • The developed method produces cost-efficient network models.
    • Interconnected L5PCs can amplify delta-range oscillatory inputs, independent of network size and topology.
    • This amplification is primarily mediated by the medium afterhyperpolarization from the Ca2+-activated SK current.