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Related Experiment Videos

Two miscarriages, consecutive or non-consecutive, does it change something?

C Cardinale1, J Berbis2, C Chau1

  • 1Service de gynécologie-obstétrique, gynepole, hôpital Nord, AP-HM, chemin des Bourrely, 13015 Marseille, France.

Journal of Gynecology Obstetrics and Human Reproduction
|October 11, 2017
PubMed
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This summary is machine-generated.

An etiological evaluation identifies causes for recurrent miscarriages (RM) in over half of patients, guiding effective treatments. This assessment is recommended for all women experiencing RM, irrespective of their obstetric history.

Area of Science:

  • Reproductive Medicine
  • Gynecology
  • Obstetrics

Background:

  • Recurrent miscarriage (RM) affects a significant number of women.
  • Understanding the underlying causes of RM is crucial for effective management.
  • The chronological pattern of miscarriages may influence etiological findings.

Purpose of the Study:

  • To determine the rate of anomalies identified through etiological evaluation in patients with recurrent early miscarriages.
  • To assess how miscarriage chronology (number of miscarriages, history of live birth, and succession of RM) impacts the rate of identified anomalies.

Main Methods:

  • A retrospective single-center study included patients with at least two miscarriages before 14 weeks of gestation.
  • Etiological evaluation encompassed blood glucose, antiphospholipid syndrome screening, endocrine assessment, vitamin levels, pelvic imaging, partner karyotyping, chronic endometritis, and thrombophilia screening.
Keywords:
Live birth rateObstetrical prognosisPregnancy rateRecurrent miscarriageTherapeutic

Related Experiment Videos

  • Data were analyzed based on consecutive versus non-consecutive RM and history of live birth.

    • Main Results:

    • Of 288 patients, 17.4% had uterine anomalies, and 24 cases of chronic endometritis were found.
    • Thrombophilic disorders, endocrine disorders, and vitamin deficiencies were common findings.
    • No significant differences in anomaly rates were observed based on the succession of RM or history of live birth, except for patient age.

    Conclusions:

    • Etiological evaluation identifies causes or risk factors for RM in over half of cases.
    • An adapted and efficient therapeutic approach can be offered based on the evaluation findings.
    • This comprehensive etiological evaluation should be offered to all patients with recurrent miscarriages, regardless of their obstetric history.