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Related Experiment Videos

Core-shell microspheres with porous nanostructured shells for liquid chromatography.

Adham Ahmed1, Kevin Skinley1, Stephanie Herodotou1

  • 1Thermo Fisher Scientific, Runcorn, UK.

Journal of Separation Science
|October 11, 2017
PubMed
Summary

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Core-shell particles offer faster, more efficient high-performance liquid chromatography (HPLC) separations with lower backpressure. This review covers their fabrication, advantages over other particle types, and diverse applications for various analytes.

Area of Science:

  • Analytical Chemistry
  • Materials Science

Background:

  • High-performance liquid chromatography (HPLC) relies on advanced stationary phases for efficient separations.
  • Core-shell particles, featuring a solid core and porous shell, have emerged as a significant development in HPLC stationary phase technology over the past decade.

Purpose of the Study:

  • To review the advancements and benefits of core-shell particles (superficially porous particles) compared to non-porous and fully porous particles.
  • To detail the fabrication methodologies for core-shell particles.
  • To discuss the applications of various core-shell particle types in HPLC.

Main Methods:

  • Review of existing literature on core-shell particle synthesis and applications.
  • Comparative analysis of core-shell particles versus traditional porous and non-porous particles.
Keywords:
core-shell particlesfast liquid chromatographyhybrid particlesspheres-on-sphere silicasuperficially porous particles

Related Experiment Videos

  • Discussion of fabrication techniques including silica-based and non-silica shell materials.

    • Main Results:

    • Core-shell particles demonstrate superior performance in HPLC, enabling faster separations and reduced backpressure.
    • These particles are effective for a broad spectrum of analytes, including small and large molecules, ionic and neutral compounds, and biomolecules.
    • Various fabrication methods yield diverse core-shell structures, including silica and spheres-on-sphere designs.

    Conclusions:

    • Core-shell particles represent a key innovation in HPLC stationary phase development, offering significant performance advantages.
    • Continued research into novel materials and fabrication techniques will further enhance HPLC capabilities.
    • The versatility of core-shell particles makes them suitable for a wide array of analytical challenges in chromatography.