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Programmed Death-Ligand 1 Expression and Its Correlation with Lymph Node Metastasis in Papillary Thyroid Carcinoma
Hyo Jung An1, Gyung Hyuck Ko2,3,4, Jeong-Hee Lee2,3,4
1Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Korea.
Journal of Pathology and Translational Medicine
|October 11, 2017
Summary
Programmed death-ligand 1 (PD-L1) expression in papillary thyroid carcinoma (PTC) correlates with lymph node metastasis. PD-L1 may serve as a predictive marker for lymph node involvement in PTC patients.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- The role of programmed death-ligand 1 (PD-L1) in cancer immunotherapy is established, but its expression in papillary thyroid carcinoma (PTC) remains understudied.
- Limited data exist on PD-L1 and programmed cell death protein 1 (PD-1) expression in PTC and their association with clinical outcomes.
Purpose of the Study:
- To investigate the expression of PD-L1 and PD-1 in papillary thyroid carcinoma.
- To analyze the correlation between PD-L1/PD-1 expression and lymph node (LN) metastasis in PTC.
Main Methods:
- Clinicopathological data from 116 PTC patients were analyzed.
- Tissue microarrays of PTC samples were assessed for PD-L1 and PD-1 expression by two pathologists.
- Expression levels were graded based on proportion and intensity in tumor and inflammatory cells.
Main Results:
- A significant correlation was observed between PD-1 and PD-L1 expression proportions in both PTC cells and peritumoral lymphoid cells.
- The proportion of PD-L1 expression in PTC cells was significantly associated with lymph node metastasis (p=.036).
Conclusions:
- PD-L1 expression is a valuable predictive marker for lymph node metastasis in papillary thyroid carcinoma.
- Targeting PD-L1 through immunomodulating therapies could be a potential treatment strategy for PTC patients with lymph node metastasis.