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High Albumin Expression Promotes Tumor Progression in Gastric Adenocarcinoma
Hyo Jung An1,2,3, Min Hye Kim4, Dae Hyun Song5,2,3
1Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.
In Vivo (Athens, Greece)
|April 28, 2026
Summary
Tumor cell albumin in gastric adenocarcinoma correlates with tumor progression and enhances cell motility and growth. While not an independent prognostic marker, it indicates aggressive tumor biology.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Albumin is abundant in human plasma and extensively studied in cancer.
- Its significance and intracellular role in gastric adenocarcinoma cells remain unclear.
Purpose of the Study:
- To investigate the clinicopathologic significance of tumor-cell albumin in gastric adenocarcinoma.
- To elucidate the intracellular role of tumor-cell albumin in cancer progression.
Main Methods:
- Analyzed 187 gastric adenocarcinoma patients undergoing gastrectomy.
- Assessed albumin expression via immunohistochemistry and correlated with clinicopathologic variables and survival (DFS, DSS).
- Examined albumin's functional role in vitro using cell lines and siRNA-mediated knockdown.
Main Results:
- High albumin expression associated with larger tumor size and advanced T and N stages.
- Albumin expression did not independently predict disease-free survival (DFS) or disease-specific survival (DSS).
- In vitro, albumin knockdown impaired cell migration and proliferation.
Conclusions:
- Tumor-cell albumin correlates with gastric cancer progression.
- Albumin contributes intracellularly to tumor cell motility and growth.
- Albumin may serve as a marker of aggressive tumor biology in gastric cancer.
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