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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

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Related Experiment Video

Updated: Jul 2, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Time-Dependent Inflammatory Cytokine Responses in a Human Fetal Membrane Dual-Compartment Model.

Katharina Sterenczak1, Yasmin Engist2, Luise Koepke2

  • 1Department of Obstetrics and Gynecology, Rostock University Medical Center, Rostock, Germany; katharina.sterenczak@kliniksued-rostock.de.

In Vivo (Athens, Greece)
|June 30, 2026
PubMed
Summary

Investigating preterm birth inflammation, this study used a human fetal membrane model. Preceding administration of rytvela reduced interleukin-1β levels, suggesting timing impacts inflammatory responses.

Keywords:
Preterm birthcytokinesex vivo modelfetal membranesintra-amniotic inflammationrytvela

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Multicellular Human Alveolar Model Composed of Epithelial Cells and Primary Immune Cells for Hazard Assessment

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Last Updated: Jul 2, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Multicellular Human Alveolar Model Composed of Epithelial Cells and Primary Immune Cells for Hazard Assessment
09:27

Multicellular Human Alveolar Model Composed of Epithelial Cells and Primary Immune Cells for Hazard Assessment

Published on: May 6, 2020

Area of Science:

  • Reproductive Biology
  • Immunology
  • Perinatal Medicine

Background:

  • Preterm birth is a major cause of neonatal morbidity and mortality.
  • Inflammation at the feto-maternal interface is central to preterm birth pathogenesis.
  • Human fetal membrane models offer a relevant platform for studying inflammation.

Purpose of the Study:

  • To investigate inflammatory mechanisms in human fetal membranes.
  • To evaluate the efficacy of targeted interventions like rytvela.
  • To analyze time- and compartment-resolved inflammatory responses.

Main Methods:

  • Human fetal membrane explants cultured in a dual-compartment system.
  • Inflammation induced by lipopolysaccharide (LPS) application.
  • Quantification of interleukin (IL)-1β and IL-6; evaluation of rytvela administration timing.

Main Results:

  • LPS induced time- and dose-dependent increases in IL-1β and IL-6.
  • IL-6 increased from 6 hours; IL-1β increased at later time points (24-48 hours).
  • Preceding rytvela administration lowered IL-1β levels compared to simultaneous or delayed treatment; IL-6 was unaffected.

Conclusions:

  • The dual-compartment model allows time-resolved analysis of fetal membrane inflammation.
  • Rytvela's timing influences IL-1β levels, highlighting pathway-specific regulation.
  • Inflammatory responses in fetal membranes are subject to timing-dependent modulation.