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Related Experiment Videos

Does Isolation of Enterococcus Affect Outcomes in Intra-Abdominal Infections?

James M Sanders1, Jeffrey M Tessier1, Robert Sawyer2

  • 11 JPS Health Network , Fort Worth, Texas.

Surgical Infections
|October 11, 2017
PubMed
Summary

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This summary is machine-generated.

Enterococcus isolation in intra-abdominal infections (IAIs) did not predict poor outcomes. Current antimicrobial treatment approaches for IAIs do not require alteration based on Enterococcus presence.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Surgical Infections

Background:

  • Enterococci are frequently isolated in intra-abdominal infections (IAIs) and are associated with adverse clinical outcomes.
  • The clinical significance and optimal antimicrobial treatment strategy for IAIs involving Enterococcus remain debated.

Purpose of the Study:

  • To determine if Enterococcus isolation in IAIs independently predicts adverse clinical outcomes.
  • To evaluate if the presence of Enterococcus necessitates an altered antimicrobial treatment approach for IAIs.

Main Methods:

  • Post hoc analysis of the Study to Optimize Peritoneal Infection Therapy (STOP-IT) trial database.
  • Stratification of 518 patients into Enterococcus-positive (n=50) and Enterococcus-negative groups.
  • Uni-variable and multi-variable analyses to assess Enterococcus as a predictor of a composite outcome (surgical site infection, recurrent IAI, or death).
Keywords:
EnterococcusStudy to Optimize Peritoneal Infection Therapy (STOP-IT)intra-abdominal infection

Related Experiment Videos

Main Results:

  • Enterococcus spp. were identified in 50 patients, with Enterococcus faecalis being predominant.
  • No statistically significant differences were observed in baseline characteristics, infection origins, or antibiotic utilization between groups.
  • Clinical outcomes, including surgical site infection, recurrent IAI, and death, were comparable between Enterococcus-positive and negative groups.
  • Multi-variable analysis confirmed that Enterococcus isolation did not independently predict the composite outcome (OR 1.53, p=0.22).

Conclusions:

  • Enterococcus is not a more common pathogen in health-care-associated IAIs.
  • Isolation of Enterococcus in IAIs is not an independent risk factor for adverse composite outcomes.
  • Current antimicrobial treatment strategies for IAIs do not require modification based solely on Enterococcus presence, though larger studies are needed.