Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Migraine, menopause and hormone replacement therapy.

E Anne MacGregor1

  • 1Barts Sexual Health Centre, London, UK.

Post Reproductive Health
|October 11, 2017
PubMed
Summary

Perimenopause increases migraine and vasomotor symptoms. Hormone therapy with stable estrogen can help estrogen-withdrawal migraine and hot flashes, while continuous progestogens are preferred over cyclical ones.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perimenopausal migraine: a narrative review.

Climacteric : the journal of the International Menopause Society·2026
Same author

Hormone replacement therapy (HRT) in perimenopausal women with migraine.

Post reproductive health·2024
Same author

Effect of galcanezumab in women with episodic migraine meeting criteria for menstrually related migraine: A post hoc analysis of EVOLVE-1 and EVOLVE-2.

Headache·2023
Same author

Safety and efficacy of ubrogepant for the acute treatment of perimenstrual migraine attacks: A post hoc analysis.

Headache·2023
Same author

Efficacy of lasmiditan for the acute treatment of perimenstrual migraine.

Cephalalgia : an international journal of headache·2022
Same author

Time trends in contraceptive prescribing in UK primary care 2000-2018: a repeated cross-sectional study.

BMJ sexual & reproductive health·2021

Area of Science:

  • Reproductive Endocrinology
  • Neurology
  • Women's Health

Background:

  • Perimenopause is associated with increased migraine prevalence and bothersome vasomotor symptoms.
  • Fluctuating estrogen levels during perimenopause impact migraine, with estrogen withdrawal potentially triggering migraine without aura and high estrogen levels possibly triggering migraine with aura.

Purpose of the Study:

  • To review the management of migraine and vasomotor symptoms during perimenopause.
  • To discuss the role of hormone therapy and non-hormonal options.

Main Methods:

  • Literature review of studies on perimenopause, migraine, vasomotor symptoms, and treatment options.
  • Analysis of the effects of estrogen and progestogen on migraine and menopausal symptoms.

Main Results:

  • Estrogen replacement therapy can benefit estrogen-withdrawal migraine and vasomotor symptoms.
  • Physiological doses of natural estrogen are generally safe for migraine aura, unlike contraceptive doses of ethinylestradiol.
  • Continuous progestogens are preferred over cyclical progestogens due to potential adverse effects of cyclical progestogens on migraine.
  • Non-hormonal options like escitalopram and venlafaxine show efficacy for both conditions.

Conclusions:

  • Hormone therapy can be effective for managing migraine and vasomotor symptoms in perimenopause when administered appropriately.
  • Careful selection of hormone therapy, prioritizing stable estrogen and continuous progestogens, is crucial.
  • Limited non-hormonal options exist, but some antidepressants show promise.
Keywords:
Estrogenhormone replacement therapymenopausemigrainevasomotor symptoms

Related Experiment Videos