Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Studying the Cytoskeleton01:17

Studying the Cytoskeleton

10.3K
The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...
10.3K
Laminins are the Adhesive Proteins of Basal Lamina00:55

Laminins are the Adhesive Proteins of Basal Lamina

3.6K
Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biocompatibility Assessment of an Injectable Carbon Nanotube-Functionalized Reverse Thermal Gel for Cardiac Tissue Engineering Applications.

ACS applied bio materials·2025
Same author

Defective Biomechanics and Pharmacological Rescue of Human Cardiomyocytes with Filamin C Truncations.

International journal of molecular sciences·2024
Same author

EMID2 is a novel biotherapeutic for aggressive cancers identified by in vivo screening.

Journal of experimental & clinical cancer research : CR·2024
Same author

Expanded Glass for Thermal and Acoustic Insulation from Recycled Post-Consumer Glass and Textile Industry Process Waste.

Materials (Basel, Switzerland)·2023
Same author

Cellular Biomechanic Impairment in Cardiomyocytes Carrying the Progeria Mutation: An Atomic Force Microscopy Investigation.

Langmuir : the ACS journal of surfaces and colloids·2022
Same author

Piezo1 Channel as a Potential Target for Hindering Cardiac Fibrotic Remodeling.

International journal of molecular sciences·2022

Related Experiment Video

Updated: Feb 21, 2026

Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence
06:23

Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence

Published on: January 17, 2025

1.3K

A Perspective on the Experimental Techniques for Studying Lamins.

Ilaria Pecorari1, Daniele Borin2, Orfeo Sbaizero3

  • 1Department of Engineering and Architecture, University of Trieste, Via Valerio 10, 34127 Trieste, Italy. ILARIA.PECORARI@phd.units.it.

Cells
|October 11, 2017
PubMed
Summary

Lamins, structural proteins in the nuclear lamina, are crucial for cell health. Studying laminopathies and cancer reveals their importance and drives research into new diagnostic and therapeutic strategies.

Keywords:
experimental techniqueslaminsmechanicsmicroscopyspectroscopy

More Related Videos

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells
06:56

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells

Published on: September 28, 2020

1.3K
Laser-assisted Microdissection LAM as a Tool for Transcriptional Profiling of Individual Cell Types
09:31

Laser-assisted Microdissection LAM as a Tool for Transcriptional Profiling of Individual Cell Types

Published on: May 10, 2016

9.8K

Related Experiment Videos

Last Updated: Feb 21, 2026

Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence
06:23

Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence

Published on: January 17, 2025

1.3K
Generating a Fractal Microstructure of Laminin-111 to Signal to Cells
06:56

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells

Published on: September 28, 2020

1.3K
Laser-assisted Microdissection LAM as a Tool for Transcriptional Profiling of Individual Cell Types
09:31

Laser-assisted Microdissection LAM as a Tool for Transcriptional Profiling of Individual Cell Types

Published on: May 10, 2016

9.8K

Area of Science:

  • Cell Biology
  • Biochemistry
  • Genetics

Background:

  • Lamins are type V intermediate filaments forming the nuclear lamina and nucleoplasm.
  • Mutations in A-type lamins cause laminopathies, a class of genetic diseases.
  • Lamins are implicated in various pathological conditions, including cancer.

Purpose of the Study:

  • To review experimental techniques used for studying lamins.
  • To provide researchers with an overview of established and novel methodologies.
  • To highlight the potential for improved diagnostics and therapeutics through lamin research.

Main Methods:

  • Review of diverse experimental techniques for lamin investigation.
  • Multidisciplinary approaches integrating various scientific fields.
  • Analysis of existing literature on lamin structure, function, and disease association.

Main Results:

  • Lamins play a critical role in nuclear structure and cellular function.
  • Lamin research has revealed links to numerous diseases, particularly laminopathies.
  • Various techniques offer insights into lamin behavior and involvement in pathology.

Conclusions:

  • Understanding lamin functions is vital for comprehending cellular processes and disease mechanisms.
  • Continued research into laminopathies and cancer holds promise for clinical advancements.
  • This review serves as a resource for scientists exploring novel research avenues in lamin biology.