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Updated: Feb 21, 2026

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Published on: April 21, 2023
Finer Needles Reduce Pain Associated With Injection of Local Anesthetic Using a Minimal Insertion Injection Technique
Blake R Zelickson1, Leonard H Goldberg, Marc K Rubenzik
1*All authors are affiliated with DermSurgery Associates, Houston, Texas; Houston Methodist Hospital, Houston, Texas.
Background:
The injection of local anesthetic into the skin is often the only memorable event described by the patient after dermatologic procedures.
Objective:
The authors compared the pain felt during injection of local anesthetic using a minimal needle insertion technique with a 30- or 33-gauge needle.
Materials And Methods:
Three hundred eighteen patients with tumors on the head and neck were injected with lidocaine using a previously described technique with either a 30- or 33-gauge needle. After injection, patients were surveyed using the visual assessment scale for pain.
Results:
Seventy-seven percent of patients felt no pain with injection on the face using a 33-gauge needle compared with 64% with a 30 gauge, whereas 94% of patients felt no pain on the scalp with a 33-gauge needle compared with 54% with a 30 gauge. Visual analog scale scores were also significantly decreased on the face and scalp using the smaller needle. There was no difference in pain between the 2 needles with injection on the neck.
Conclusion:
This study further validates the use of this technique for the injection of lidocaine and the preference of a 33 gauge over a 30-gauge needle for the initial injection on the face and scalp.
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