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Updated: Feb 21, 2026
Zebrafish Model of Neuroblastoma Metastasis
Published on: March 14, 2021
Neuroblastoma Metastases: Leveraging the Avian Neural Crest
Tina Zheng1, Marie Ménard1, William A Weiss1
1Departments of Neurology, Pediatrics, and Neurosurgery, Brain Tumor Research Center, University of California, San Francisco, CA 94158, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA.
Abstract:
Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diagnosis. In this issue of Cancer Cell, Delloye-Bourgeois and colleagues demonstrate that neuroblastoma cell lines and patient-derived xenografts engraft and adopt a metastatic program in chick embryos. They identify Sema3C as a candidate switch that regulates metastatic spread.
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