Association between TNF, IL1B, IL6, IL10 and IFNG polymorphisms and recurrent miscarriage: a case control study

Area of Science:

• Reproductive Immunology
• Human Genetics

Background:

• Recurrent miscarriage (RM) often has an unexplained etiology, affecting approximately 50% of cases.
• Cytokines are crucial for maintaining pregnancy, and their gene polymorphisms may influence RM risk.
• Investigating cytokine gene polymorphisms offers insights into the genetic factors contributing to RM.

Purpose of the Study:

• To examine the association between specific cytokine gene polymorphisms and the risk of recurrent miscarriage in a Chinese population.
• To identify potential genetic markers for predicting RM susceptibility or protection.

Main Methods:

• Genotyping of eight cytokine gene polymorphisms (TNF -238G>A, TNF -308G>A, IL1B -511T>C, IL1B 3954C>T, IL6 -174G>C, IL6 -634C>G, IL10 -1082A>G, IFNG 874A>T) in 775 RM patients and 805 controls.
• Logistic regression analysis was employed to calculate odds ratios (ORs) and assess the statistical significance of the associations.

Main Results:

• The IL1B -511 T>C polymorphism showed a significantly increased risk of RM associated with the mutant (CC) genotype (OR: 1.377; P=0.026).
• The IL6 -634C>G polymorphism demonstrated a decreased risk of RM for both heterozygous (CG) (OR: 0.614; P<0.001) and mutant (GG) (OR: 0.414; P=0.001) genotypes.

Conclusions:

• The IL1B -511 T>C polymorphism is identified as a potential risk factor for recurrent miscarriage.
• The IL6 -634C>G polymorphism may confer a protective effect against the development of recurrent miscarriage.