Related Experiment Video
Updated: Feb 21, 2026

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats
Published on: May 24, 2018
Air and Bone Conduction Frequency-specific Auditory Brainstem Response in Children with Agenesis of the External
Pricila Sleifer1, Dayane Domeneghini Didoné2, Ísis Bicca Keppeler1
1Department of Human Health and Communication, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Insights
Tone-evoked auditory brainstem responses (tone-ABR) using bone conduction accurately assess cochlear function in infants with external auditory canal agenesis. Air conduction thresholds were elevated, confirming conductive hearing loss in these children.
Area of Science:
- Audiology
- Pediatric Otolaryngology
- Neuroscience
Background:
- Tone-evoked auditory brainstem responses (tone-ABR) are crucial for diagnosing hearing issues in infants up to 12 months.
- External and middle ear malformations can complicate hearing assessments in young children.
- Frequency-specific auditory stimuli via air and bone conduction aid in detailed hearing profile characterization.
Purpose of the Study:
- To compare tone-ABR results using air and bone conduction in infants under 12 months with external auditory canal agenesis.
- To evaluate the effectiveness of bone conduction tone-ABR in assessing cochlear integrity in this specific pediatric population.
Main Methods:
- A cross-sectional, observational study involving 32 children (1-12 months old) with external auditory canal agenesis.
- Tone-ABR testing was performed using air and bone conduction at 500 Hz and 2000 Hz.
- Data analysis focused on comparing thresholds between air and bone conduction, and between genders and ears.
Main Results:
- Significantly elevated tone-ABR thresholds were observed for air conduction at 500 Hz and 2000 Hz.
- Bone conduction tone-ABR thresholds remained within normal limits for both ears.
- No significant differences in thresholds were found between genders or between the left and right ears for most comparisons.
Conclusions:
- Bone conduction tone-ABR effectively assesses cochlear integrity in infants with external auditory canal agenesis.
- Conductive hearing loss, indicated by elevated air conduction thresholds, does not impact bone conduction thresholds in this cohort.
- Tone-ABR via bone conduction is a valuable diagnostic tool for this specific group of infants.
Abstract:
Introduction The tone-evoked auditory brainstem responses (tone-ABR) enable the differential diagnosis in the evaluation of children until 12 months of age, including those with external and/or middle ear malformations. The use of auditory stimuli with frequency specificity by air and bone conduction allows characterization of hearing profile. Objective The objective of our study was to compare the results obtained in tone-ABR by air and bone conduction in children until 12 months, with agenesis of the external auditory canal. Method The study was cross-sectional, observational, individual, and contemporary. We conducted the research with tone-ABR by air and bone conduction in the frequencies of 500 Hz and 2000 Hz in 32 children, 23 boys, from one to 12 months old, with agenesis of the external auditory canal. Results The tone-ABR thresholds were significantly elevated for air conduction in the frequencies of 500 Hz and 2000 Hz, while the thresholds of bone conduction had normal values in both ears. We found no statistically significant difference between genders and ears for most of the comparisons. Conclusion The thresholds obtained by bone conduction did not alter the thresholds in children with conductive hearing loss. However, the conductive hearing loss alter all thresholds by air conduction. The tone-ABR by bone conduction is an important tool for assessing cochlear integrity in children with agenesis of the external auditory canal under 12 months.
Related Concept Videos
The Cochlea
Auditory Pathway
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
Anatomy of the Ear
Hearing
The Auditory Ossicles
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
Perceiving Loudness, Pitch, and Location
Place theory, or place coding, suggests that different pitches are heard because various sound waves activate specific locations along the cochlea's basilar membrane. The brain determines the pitch of a sound by...

