Related Experiment Video
Updated: Feb 21, 2026
08:15
3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
Published on: August 4, 2020
7.0K
Custom Repair of Mandibular Bone Defects with 3D Printed Bioceramic Scaffolds.
11 State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, China.
Journal of Dental Research
|October 12, 2017
Summary
Custom 3D-printed bioceramic scaffolds using magnesium-substituted wollastonite (CSi-Mg10) show superior bone regeneration in rabbit jaw defects. These mechanically strong implants promote enhanced osteogenesis compared to traditional materials.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Orthopedic Engineering
Background:
- Alveolar bone defects pose challenges for reconstruction due to the need for implants with precise shape and mechanical strength.
- Current bioceramic scaffolds often lack the ideal balance of mechanical properties, degradation rate, and osteogenic potential.
Purpose of the Study:
- To develop and evaluate custom-shaped, mechanically robust bioceramic scaffolds for alveolar bone defect repair.
- To assess the osteogenic capability of a novel magnesium-substituted wollastonite (Ca90%Mg10%SiO3; CSi-Mg10) scaffold in a rabbit mandibular defect model.
Main Methods:
- Computed tomography (CT) imaging was used to create patient-specific 3D models of mandibular defects.
- 3-dimensional (3D) printing (robocasting) fabricated CSi-Mg10 bioceramic scaffolds, alongside beta-tricalcium phosphate (TCP), wollastonite (CSi), and bredigite (Bred) scaffolds for comparison.
- In vitro physicochemical characterization (porosity, dissolution, flexural strength) and in vivo implantation in rabbit mandibular defects were performed.
Main Results:
- CSi-Mg10 scaffolds exhibited controlled in vitro dissolution (~7% weight loss) and high initial flexural strength (31 MPa), maintaining resistance during soaking.
- Despite larger pore dimensions, CSi-Mg10 had lower porosity due to sintering shrinkage, but demonstrated superior in vivo osteogenic capability after 16 weeks compared to TCP, CSi, and Bred.
- The CSi-Mg10 scaffolds precisely matched the macro and micro-geometry of the mandibular defects.
Conclusions:
- Customized 3D-printed CSi-Mg10 scaffolds offer a promising biomaterial solution for alveolar bone defect repair.
- The enhanced osteogenic potential and mechanical stability of CSi-Mg10 suggest significant clinical applicability in regenerative dentistry and orthopedics.
