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Related Experiment Videos

DNA polymorphism in the human Thy-1 gene.

R A Gatti1, R Shaked, S Wei

  • 1Department of Pathology, University of California, Los Angeles.

Human Immunology
|July 1, 1988
PubMed
Summary

Researchers identified a new genetic marker in the human Thy-1 gene, revealing two common alleles. This discovery offers a valuable tool for studying genetic diseases linked to chromosome 11q22.3.

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Area of Science:

  • Genetics
  • Molecular Biology
  • Neuroscience

Background:

  • Thy-1 is a membrane glycoprotein primarily found in brain and lymphoid tissues.
  • The human Thy-1 gene is mapped to chromosome 11q22.3.
  • While mice have distinct Thy-1 alleles, none were previously identified in humans.

Purpose of the Study:

  • To investigate genetic variations within the human Thy-1 gene.
  • To identify potential genetic markers for disease linkage studies.

Main Methods:

  • Analysis of the human Thy-1 gene using MspI restriction enzyme digestion.
  • Genotyping of a northern European population to determine allele frequencies.

Main Results:

  • A polymorphic MspI site was identified within the human Thy-1 gene.

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  • Two alleles, designated 8 and 9, were found.
  • Allele 8 frequency was 0.7, and Allele 9 frequency was 0.3 in the studied population.

    • Conclusions:

    • The human Thy-1 gene exhibits genetic polymorphism.
    • Thy-1 serves as a potential genetic marker for linkage analysis of diseases near chromosome 11q22.3.