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The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
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The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
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Chapter 10: Sinonasal malignancies.

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    Area of Science:

    • Oncology
    • Otorhinolaryngology

    Background:

    • Malignant tumors of the sinonasal tract are uncommon head and neck cancers.
    • Patients often present with unilateral symptoms, mimicking inflammatory conditions, necessitating high clinical suspicion for early diagnosis.

    Purpose of the Study:

    • To review the classification, clinical presentation, diagnostic investigations, and management principles of malignant sinonasal tumors.

    Main Methods:

    • Review of sinonasal malignancy classification, including epithelial and nonepithelial origins.
    • Discussion of diagnostic modalities like computed tomography (CT) and magnetic resonance imaging (MRI).
    • Outline of multimodality treatment approaches, emphasizing surgery and radiotherapy.

    Main Results:

    • Established risk factors include occupational exposure in woodworking, metal, textile, and leather industries.
    • Accurate histopathology and staging are crucial for treatment planning.
    • Imaging (CT and MRI) is essential for determining local disease extent.

    Conclusions:

    • Sinonasal malignancies require a high index of suspicion for early detection.
    • Multimodality therapy, including surgical excision and postoperative radiotherapy, is the cornerstone of management.