An integrated microfluidic system using a micro-fluxgate and micro spiral coil for magnetic microbeads trapping and
Xuecheng Sun1, Zhu Feng1, Shaotao Zhi1
1Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Department of Micro/Nano Electronics, School of electronic information and electrical engineering, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai, 200240, China.
Abstract:
We report an innovative integrated microfluidic platform based on micro-fluxgate and micro-coils for trapping and detecting magnetic beads. A micro-spiral coil fabricated by microfabrication technology is used to trap the magnetic beads, and the micro-fluxgate is employed to detect the weak magnetic field induced by the trapped magnetic beads. The fabrication process of the magnetic bead trapping system using a micro-coil is highly compatible with that of the micro-fluxgate sensor, making fabrication of this integrated microfluidic system convenient and efficient. It is observed that the magnetic bead trapping ratio increases as the number of magnetic beads is increased with a flow rate of 5 to 16.5 μL·min-1. Samples spiked with different concentrations of magnetic beads can be distinguished clearly using the micro-fluxgate sensor in this microfluidic system. In this study, the results demonstrate that the microfluidic system traps and detects magnetic beads efficiently and is a promising candidate for biomarker capture and detection.
