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Lid-Parallel Conjunctival Folds and Their Ability to Predict Dry Eye
1Optometry and Vision Research (H.P.), Weinheim, Germany; School of Optometry and Vision Sciences (H.P.), Cardiff University, Cardiff, United Kingdom; Ophthalmic Research Group (H.P., S.B.), Life and Health Sciences, Aston University, Birmingham, United Kingdom; and Höhere Fachschule für Augenoptik Köln (HFAK) (S.B.), Cologne, Germany.
Eye & Contact Lens
|October 13, 2017
Summary
Lid-parallel conjunctival folds (LIPCOF) show high predictive ability for dry eye disease. This simple test is a promising diagnostic tool for clinicians managing dry eye patients.
Area of Science:
- Ophthalmology
- Ocular Surface Disease
Background:
- Lid-parallel conjunctival folds (LIPCOF) are observed in dry eye diagnoses.
- Approximately 70% of European clinicians utilize LIPCOF in dry eye clinics.
Purpose of the Study:
- To investigate the sensitivity and specificity of LIPCOF in predicting dry eye.
- To evaluate LIPCOF as a diagnostic tool for dry eye disease.
Main Methods:
- Analysis of Ocular Surface Disease Index (OSDI), noninvasive tear break-up time (NIKBUT), and LIPCOF from 148 patient reports.
- Patients were categorized into symptomatic dry eye (OSDI ≥15) and composite dry eye (OSDI ≥15 and NIKBUT ≤9 sec) groups.
Main Results:
- LIPCOF (temporal, nasal, and sum) significantly correlated with OSDI and NIKBUT.
- LIPCOF effectively discriminated between healthy and dry eye subjects (P≤0.001).
- Areas under the ROC curve for LIPCOF Sum ranged from 0.771 to 0.798, indicating strong predictive ability.
Conclusions:
- LIPCOF demonstrates significant potential as a diagnostic test for dry eye.
- The findings support the clinical utility of LIPCOF in identifying dry eye conditions.
