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Related Experiment Videos

Eppur Si Muove: ferritin is essential in modulating inflammation.

K Sharif1,2, V Vieira Borba1,2,3, G Zandman-Goddard1,2,4

  • 1Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.

Clinical and Experimental Immunology
|October 13, 2017
PubMed
Summary

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Ferritin is now understood to be a pathogenic molecule, not just an inflammation marker. Emerging evidence supports this, opening new avenues for treating hyperferritinaemia-related diseases.

Area of Science:

  • Biochemistry
  • Pathophysiology
  • Molecular Medicine

Background:

  • Ferritin, a protein primarily known for iron storage, was discovered last century.
  • Traditionally viewed as a non-specific acute-phase reactant, its role in disease is under re-evaluation.

Purpose of the Study:

  • To investigate the hypothesis that ferritin acts as a pathogenic molecule.
  • To explore the implications of ferritin's pathogenic role in diseases associated with hyperferritinaemia.

Main Methods:

  • Review of emerging scientific evidence.
  • Analysis of ferritin's role beyond inflammation.

Main Results:

  • Recent evidence supports the hypothesis of ferritin's contributory role in disease pathogenesis.
Keywords:
acute phase reactantferritinhyperferritenemic syndromemacrophage activating syndromepro-inflammation

Related Experiment Videos

  • Ferritin's function extends beyond being a mere indicator of inflammation.

    • Conclusions:

    • Ferritin's pathogenic potential is increasingly recognized.
    • Understanding ferritin as a pathogenic molecule offers new therapeutic targets for hyperferritinaemia.