Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Onco-proteogenomics: Multi-omics level data integration for accurate phenotype prediction.

Lampros Dimitrakopoulos1,2,3, Ioannis Prassas2, Eleftherios P Diamandis1,2,3,4

  • 1a Department of Laboratory Medicine and Pathobiology , University of Toronto , Toronto , ON , Canada.

Critical Reviews in Clinical Laboratory Sciences
|October 14, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The International Society for Enzymology: a glorious history, a golden legacy.

Clinical chemistry and laboratory medicine·2018
Same author

Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies.

Molecular & cellular proteomics : MCP·2018
Same author

Unraveling endometriosis-associated ovarian carcinomas using integrative proteomics.

F1000Research·2018
Same author

Expression profile of human tissue kallikrein 15 provides preliminary insights into its roles in the prostate and testis.

Clinical biochemistry·2018
Same author

Biochemical characterization of human tissue kallikrein 15 and examination of its potential role in cancer.

Clinical biochemistry·2018
Same author

Towards personalized tumor markers.

NPJ precision oncology·2018
Same journal

Indirect methods for the verification of reference intervals in laboratory medicine.

Critical reviews in clinical laboratory sciences·2026
Same journal

Sustainability and waste reduction in clinical laboratories.

Critical reviews in clinical laboratory sciences·2026
Same journal

Aptamer-based biosensing strategies for influenza virus detection: a systematic and critical review of electrochemical and optical platforms.

Critical reviews in clinical laboratory sciences·2026
Same journal

Advancing patient safety through laboratory quality indicators in clinical pathology.

Critical reviews in clinical laboratory sciences·2026
Same journal

Blood biomarkers for the diagnosis of chorioamnionitis following preterm premature rupture of membranes: a systematic review and meta-analysis of studies since 2020.

Critical reviews in clinical laboratory sciences·2026
Same journal

Single cell mechanodeformation signatures as early biomarkers for hematological malignancies.

Critical reviews in clinical laboratory sciences·2026
See all related articles
This summary is machine-generated.

Onco-proteogenomics integrates genomics and proteomics to understand cancer biology. This approach bridges the gap between genetic information and observable traits, advancing precision medicine and patient care.

Area of Science:

  • Oncology
  • Proteomics
  • Genomics

Background:

  • Translational oncology aims to find molecular markers for cancer detection and treatment response.
  • Next-generation sequencing revolutionized cancer research, but proteomics offers a holistic view of tumor biology.
  • The proteotype, derived from DNA coding regions, largely dictates the observed cancer phenotype.

Purpose of the Study:

  • To review the individual contributions of omics technologies to cancer research.
  • To discuss technological and computational advancements enabling onco-proteogenomics.
  • To summarize current and future translational applications of onco-proteogenomics in precision medicine.

Main Methods:

  • Review of existing literature on genomics, proteomics, and mass spectrometry in cancer research.
Keywords:
Onco-proteogenomicsprecision medicineproteogenomicsrefinement of existing “omics” modelstranslational applications

Related Experiment Videos

  • Discussion of technological advancements in omics data generation and analysis.
  • Exploration of computational strategies for integrating multi-omics data.

    • Main Results:

    • Genomics and proteomics provide complementary insights into tumor biology.
    • Mass spectrometry has matured as a key tool for proteomic analysis.
    • The integration of omics data has led to the development of onco-proteogenomics.

    Conclusions:

    • Onco-proteogenomics holds significant promise for advancing precision medicine.
    • This integrated approach can enhance personalized patient management in oncology.
    • Future research will focus on refining onco-proteogenomic strategies for clinical application.