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Related Experiment Video

Updated: Feb 21, 2026

A Multimodal Wide-Field Fourier-Transform Raman Microscope
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Combined multi-distance frequency domain and diffuse correlation spectroscopy system with simultaneous data

Stefan A Carp1, Parisa Farzam1, Norin Redes2

  • 1Harvard Medical School, Massachusetts General Hospital, Martinos Center for Biomedical Imaging, 149 13th St., Charlestown, MA 02129, USA.

Biomedical Optics Express
|October 14, 2017
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Summary

The new MetaOx instrument combines frequency domain near infrared spectroscopy (FD-NIRS) and diffuse correlation spectroscopy (DCS) for non-invasive tissue oxygen metabolism monitoring. This integrated system enables real-time assessment of blood flow and oxygenation, advancing physiological and pathological studies.

Keywords:
(120.4640) Optical instruments(120.6200) Spectrometers and spectroscopic instrumentation(170.1470) Blood or tissue constituent monitoring

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Area of Science:

  • Biomedical Engineering
  • Physiological Monitoring
  • Optical Spectroscopy

Background:

  • Non-invasive tissue assessment is crucial for understanding physiological and pathological states.
  • Frequency domain near infrared spectroscopy (FD-NIRS) and diffuse correlation spectroscopy (DCS) offer complementary data on tissue oxygenation and blood flow.
  • Quantifying tissue oxygen metabolic rate provides deeper physiological insight than individual techniques.

Purpose of the Study:

  • To introduce the first commercially available integrated instrument, the "MetaOx", for simultaneous FD-NIRS and DCS measurements.
  • To evaluate the performance of the integrated MetaOx system.
  • To demonstrate the capability of the MetaOx for real-time, in vivo physiological monitoring.

Main Methods:

  • Simultaneous acquisition of FD-NIRS and DCS data at rates exceeding 10 Hz.
  • Integration of oximetry (FD-NIRS) and blood flow (DCS) measurements.
  • Real-time data evaluation and analysis capabilities.

Main Results:

  • Characterization data confirmed performance equivalent to standalone FD-NIRS and DCS devices.
  • Demonstrated in vivo measurements of pulsation-resolved blood flow.
  • Successfully monitored forearm occlusion hemodynamics and muscle oxygen metabolic rate during exercise.

Conclusions:

  • The MetaOx instrument provides a robust and integrated platform for simultaneous FD-NIRS and DCS measurements.
  • This technology enables accurate, real-time quantification of tissue oxygen metabolic rate.
  • The MetaOx facilitates advanced non-invasive physiological and pathological research.