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Updated: Aug 14, 2026
07:06
Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach
Published on: December 1, 2011
Top Questions in ID: Pre-exposure Prophylaxis for HIV
Douglas S Krakower1,2,3, Stephanie E Cohen4, Kenneth H Mayer1,2
1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Open Forum Infectious Diseases
|October 14, 2017
Summary
Pre-exposure prophylaxis (PrEP) effectively prevents HIV. This review covers PrEP candidate identification, regimens, monitoring, use in serodiscordant couples, and addressing access barriers for clinicians and patients.
Area of Science:
- Infectious Diseases
- Public Health
- Virology
Background:
- Human Immunodeficiency Virus (HIV) remains a significant global health challenge.
- Pre-exposure prophylaxis (PrEP) is a critical biomedical intervention for HIV prevention.
- Understanding PrEP's optimal application is essential for public health strategies.
Purpose of the Study:
- To provide a comprehensive overview of HIV pre-exposure prophylaxis (PrEP).
- To guide clinicians and patients on the effective use of PrEP.
- To address various aspects of PrEP implementation and access.
Main Methods:
- This is a review article, synthesizing existing knowledge on PrEP.
- It discusses candidate identification, treatment regimens, and monitoring protocols.
- The review also covers special populations and resource availability.
Main Results:
- PrEP is highly effective in preventing HIV acquisition when used as prescribed.
- The review outlines strategies for identifying appropriate candidates for PrEP.
- It details recommended regimens, necessary evaluations, and applications in serodiscordant couples.
Conclusions:
- PrEP is a cornerstone of HIV prevention efforts.
- Successful implementation requires careful patient selection, adherence support, and addressing access barriers.
- Ongoing research and education are vital for maximizing PrEP's public health impact.
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