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ChIP and ChIP-Related Techniques: Expanding the Fields of Application and Improving ChIP Performance
Neus Visa1, Antonio Jordán-Pla2
1Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrhenius väg 20c, 10691, Stockholm, Sweden. neus.visa@su.se.
Methods in Molecular Biology (Clifton, N.J.)
|October 14, 2017
Abstract:
Protein-DNA interactions in vivo can be detected and quantified by chromatin immunoprecipitation (ChIP). ChIP has been instrumental for the advancement of epigenetics and has set the groundwork for the development of a number of ChIP-related techniques that have provided valuable information about the organization and function of genomes. Here, we provide an introduction to ChIP and discuss the applications of ChIP in different research areas. We also review some of the strategies that have been devised to improve ChIP performance.