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The mycobiome in HIV.

Christopher L Hager¹, Mahmoud A Ghannoum

¹Center for Medical Mycology, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

Current Opinion in HIV and AIDS

|October 14, 2017

Summary

Research on the fungal microbiome (mycobiome) in HIV is limited. Studies show differences in oral and respiratory mycobiome composition between HIV-infected and uninfected individuals, highlighting the need for more research.

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Area of Science:

Microbiology
Immunology
Infectious Diseases

Background:

The human microbiome, including bacteria and fungi, plays a role in health and disease.
The association between the microbiome and Human Immunodeficiency Virus (HIV) is an emerging area of research.
Most studies have focused on the bacterial component (bacteriome), with less attention paid to the fungal component (mycobiome).

Purpose of the Study:

To review recent reports on the role of the fungal community (mycobiome) in individuals with HIV.
To highlight the limited existing research on the mycobiome in the context of HIV infection.

Main Methods:

This study is a review of existing literature.
The review focuses on recent reports concerning the mycobiome and HIV.

Main Results:

Differences in the composition of the oral and respiratory mycobiome have been observed between HIV-infected and uninfected individuals.
Current research investigating the mycobiome in HIV is notably scarce.

Conclusions:

Studies on the mycobiome in HIV are significantly lacking.
Further research is crucial to understand the interplay between bacteria and fungi in the overall microbiota and their influence on the host in HIV infection.
Advances in microbiome research necessitate a deeper investigation into the fungal component's role in HIV.

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