Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

306
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
306
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

254
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
254
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

245
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
245
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

283
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
283
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

744
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
744
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

272
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
272

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ADA Standards of Medical Care in Diabetes: implications for Older Adults.

The Senior care pharmacist·2020
Same author

Understanding Clinical Laboratory Interference.

The Senior care pharmacist·2019
Same author

The Other Side of the Opioid Debate: Treating Older Adults With Chronic Pain.

The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists·2018
Same author

Getting Paid for Clinical Services.

The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists·2018
Same author

Controlling Diabetes: Continuous Glucose Monitoring for the Older Adult.

The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists·2018
Same author

Vaccines for Older Adults.

The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists·2017

Related Experiment Video

Updated: Feb 20, 2026

Probiotic Studies in Neonatal Mice Using Gavage
10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

20.9K

Demystifying Probiotics: Use in the Elderly.

Caren McHenry Martin, Gianna Bryan

    The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists
    |October 15, 2017
    PubMed
    Summary

    Healthcare professionals face challenges with the expanding research and product availability of probiotics. Understanding the gut microbiome, probiotic mechanisms, and selection criteria is vital for patient recommendations.

    Area of Science:

    • Microbiology
    • Gastroenterology
    • Pharmacology

    Background:

    • Increasing complexity of probiotic research and product landscape.
    • Need for clear guidance for healthcare professionals.
    • Growing consumer interest in probiotics for various health conditions.

    Purpose of the Study:

    • To clarify the role of probiotics in health.
    • To explain the mechanisms of probiotic action.
    • To provide criteria for selecting appropriate probiotic products.

    Main Methods:

    • Literature review of probiotic research.
    • Analysis of proposed mechanisms of action.
    • Development of a framework for product selection.

    Main Results:

    More Related Videos

    Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods
    08:38

    Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

    Published on: September 10, 2016

    25.4K
    Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
    05:45

    Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

    Published on: April 7, 2023

    4.4K

    Related Experiment Videos

    Last Updated: Feb 20, 2026

    Probiotic Studies in Neonatal Mice Using Gavage
    10:36

    Probiotic Studies in Neonatal Mice Using Gavage

    Published on: January 27, 2019

    20.9K
    Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods
    08:38

    Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

    Published on: September 10, 2016

    25.4K
    Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
    05:45

    Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

    Published on: April 7, 2023

    4.4K
    • Probiotics interact with the intestinal microbiome.
    • Evidence for probiotic efficacy varies by condition.
    • Key factors for probiotic selection include strain specificity and product quality.

    Conclusions:

    • Informed recommendations require understanding of microbiome function and probiotic science.
    • Rational patient guidance necessitates critical evaluation of probiotic evidence and product characteristics.