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Diagnostics of the neuromyelitis optica spectrum disorders (NMOSD)
Diego Franciotta1, Matteo Gastaldi2, Arianna Sala3
1Laboratory of Neuroimmunology, C. Mondino National Neurological Institute, Via Mondino 2, I-27100, Pavia, Italy. diego.franciotta@mondino.it.
Abstract:
This document presents the guidelines for anti-aquaporin-4 (AQP4) antibody testing that has been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on neuromyelitis optica spectrum disorders, indications and limits of anti-AQP4 antibody testing, instructions for result interpretation, and an agreed laboratory protocol (Appendix) are reported for the communicative community of neurologists and clinical pathologists.