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Related Concept Videos

Free Jet01:14

Free Jet

615
Free jets describe the flow of liquid exiting a reservoir through an opening into the atmosphere without resistance. The velocity (v) of the liquid jet is derived using Bernoulli's principle and expressed as:
615

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Toward jet injection by continuous-wave laser cavitation.

Carla Berrospe-Rodriguez1, Claas Willem Visser2,3, Stefan Schlautmann4

  • 1Instituto Nacional de Astrofísica, Óptica y Electrónica, Departamento de Óptica, Puebla, Pue., México.

Journal of Biomedical Optics
|October 15, 2017
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Summary

This study developed a needle-free laser-induced jet injector using microfluidic devices. Optimized parameters achieved high jet velocities for potential skin penetration, addressing global healthcare needs.

Keywords:
cavitationcontinuous-wave laserinjectionjetmicrofluidicneedle-free

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Laser Physics

Background:

  • Needle-based injections pose significant global healthcare challenges, including disease transmission and patient discomfort.
  • Development of needle-free injection technologies is crucial for improving healthcare delivery and safety.

Purpose of the Study:

  • To design and fabricate a portable, affordable needle-free jet injector using laser-induced thermocavitation.
  • To investigate parameters influencing liquid jet velocity for optimized drug delivery.

Main Methods:

  • Fabrication of glass microfluidic devices with a chamber and tapered channel.
  • Utilizing a continuous-wave laser focused on a light-absorbing solution to create thermocavitation and generate liquid jets.
  • Systematic variation of microfluidic parameters (channel diameter, taper ratio, chamber length) and meniscus dynamics.

Main Results:

  • Achieved a maximum jet velocity of 94±3 m/s with specific microfluidic dimensions (D=120 μm, n=0.25, E=200 μm).
  • Demonstrated skin penetration capability of approximately 1 mm using agarose gel phantoms, sufficient for epidermal layer targeting.
  • Identified key parameters influencing jet velocity, including channel geometry and initial meniscus position.

Conclusions:

  • Laser-induced jet injection via microfluidic devices shows promise as a needle-free alternative.
  • Further research is needed to increase injection volumes for broader medical relevance.
  • Optimized device design and understanding of fluid dynamics are critical for effective needle-free drug delivery.