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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

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Adenine-induced chronic kidney disease in rats

Vishal Diwan1, Lindsay Brown2, Glenda C Gobe1,3

  • 1UQ Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia.

Nephrology (Carlton, Vic.)
|October 15, 2017
PubMed

Insights

The chronic low-dose adenine diet in rats effectively models human chronic kidney disease (CKD) and its cardiovascular complications. This model aids in understanding CKD progression and testing new therapeutic interventions.

Area of Science:

  • Nephrology
  • Cardiovascular Research
  • Animal Models

Background:

  • Chronic kidney disease (CKD) is a progressive decline in kidney function, often leading to end-stage kidney disease (ESKD) and increased cardiovascular mortality.
  • The relationship between CKD and cardiovascular disease is bidirectional, yet many animal models fail to replicate this complexity.
  • Existing models often do not fully represent the chronic and multifaceted nature of human CKD and its associated cardiovascular risks.

Purpose of the Study:

  • To evaluate the chronic low-dose adenine diet in rats as a suitable animal model for human chronic kidney disease (CKD).
  • To highlight the model's capacity to mimic CKD-associated cardiovascular disease, a feature lacking in many other models.
  • To underscore the utility of this model for investigating CKD pathogenesis and therapeutic interventions.

Main Methods:

  • Utilized a chronic low-dose adenine diet in rats to induce progressive kidney damage.
  • Characterized the development of tubulointerstitial fibrosis, tubular atrophy, and vascular calcification.
  • Assessed the concurrent development of cardiovascular disease alongside kidney dysfunction.

Main Results:

  • The chronic low-dose adenine diet successfully induced slowly progressive kidney damage and cardiovascular disease in rats.
  • This model demonstrated features similar to human CKD, including stable kidney and cardiovascular disease progression.
  • Vascular calcification and tubulointerstitial fibrosis were key pathological findings.

Conclusions:

  • The chronic low-dose adenine diet in rats is an effective and accessible model for studying human CKD.
  • This model is particularly valuable for understanding the intricate links between CKD and cardiovascular disease.
  • It provides a platform for testing potential therapeutic strategies for CKD reversal and management.

Keywords:
adeninecardiovascular diseaseschronic kidney disease

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