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Related Experiment Videos

Microglial involvement in the development of olfactory dysfunction.

Yoojin Seo1, Hyung-Sik Kim1, Kyung-Sun Kang2,3

  • 1Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan 49241, Korea.

Journal of Veterinary Science
|October 17, 2017
PubMed
Summary
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Olfactory impairment, a common sign in aging, may signal early neurodegeneration. This review covers olfactory dysfunction, animal models, and the role of microglia in neurological disorders.

Area of Science:

  • Neuroscience
  • Gerontology
  • Immunology

Background:

  • Olfactory impairment is a prevalent clinical manifestation in the elderly, increasing with age.
  • Olfactory dysfunction is increasingly recognized as an early indicator of neurodegenerative diseases.
  • Early olfactory assessment is crucial for diagnosing neurological disorders.

Purpose of the Study:

  • To review the nature of olfactory dysfunction.
  • To highlight the utility of animal models in olfaction research.
  • To discuss the role of microglia in neurodegeneration and olfactory impairment.

Main Methods:

  • Literature review of olfactory dysfunction and neurodegeneration.
  • Introduction to common olfactory behavior tests in animal models.
Keywords:
Niemann-Pick disease type Cmicroglianeurodegenerative diseasessmell

Related Experiment Videos

  • Discussion of microglia's role in the olfactory system's neurodegenerative processes.

    • Main Results:

    • Olfactory dysfunction is a significant early marker for neurodegenerative conditions.
    • Animal models provide valuable insights into the mechanisms of olfactory impairment.
    • Microglia play a critical role in the interplay between neurons and neurodegeneration within the olfactory system.

    Conclusions:

    • Olfactory assessment is vital for early detection of neurological disorders.
    • Understanding microglia-neuron interactions in the olfactory system is key to addressing neurodegeneration.
    • This review synthesizes current knowledge on olfactory dysfunction and its links to neurological health.