Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adolescence01:18

Cognitive Development During Adolescence

693
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
693
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

1.1K
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.1K
Revisionist Views of Adolescent and Adult Cognition01:24

Revisionist Views of Adolescent and Adult Cognition

335
A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are...
335
Influence of Parents and Peers on Identity01:23

Influence of Parents and Peers on Identity

609
Adolescence is a pivotal period of identity formation, during which individuals begin to answer questions central to their sense of self, such as "Who am I?" and "Who do I hope to become?" Both parents and peers play critical roles in guiding adolescents through this complex developmental phase.
Parental Influence on Identity Development
Parents serve as primary guides and managers in an adolescent's life, offering support instrumental in decision-making and personal growth....
609
Erikson's Theory on Socioemotional Development during Adolescence01:17

Erikson's Theory on Socioemotional Development during Adolescence

1.3K
Erik Erikson's fifth stage of psychosocial development, "identity versus role confusion," is crucial during adolescence (ages 12 to 18). In this stage, adolescents face the developmental task of forging a distinct personal identity, a process influenced by social, psychological, and biological changes typical of this period. Adolescents naturally explore different roles, behaviors, and ideologies as they navigate complex questions of self-concept, asking, "Who am I?" and "What is my place in...
1.3K
Neurotransmitters01:31

Neurotransmitters

2.9K
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preliminary Evolutionary Trends of <i>Ctenophorus</i> Dragon (Lacertilia: Agamidae) Lifespans, With a New Longevity Record.

Ecology and evolution·2026
Same author

Stress-Induced Dysregulation of the Guidance Cue Receptor DCC Alters Corticolimbic Circuit Architecture.

Biological psychiatry global open science·2025
Same author

Divergent outcomes of delta 9 - tetrahydrocannabinol (THC) in adolescence on mesocortical dopamine and cognitive development in male and female mice.

Psychopharmacology·2025
Same author

Peripheral MicroRNA Signatures in Adolescent Depression.

Biological psychiatry global open science·2025
Same author

BDNF-dependent nano-organization of Neogenin and the WAVE regulatory complex promotes actin remodeling in dendritic spines.

iScience·2024
Same author

Perspective on adolescent psychiatric illness and emerging role of microRNAs as biomarkers of risk.

Journal of psychiatry & neuroscience : JPN·2024

Related Experiment Video

Updated: Feb 20, 2026

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

2.8K

Making Dopamine Connections in Adolescence.

Daniel Hoops1, Cecilia Flores1

  • 1Department of Psychiatry, Douglas Mental Health University Institute, McGill University, 6875 LaSalle Boulevard, Montreal, QC H4H 1R3, Canada.

Trends in Neurosciences
|October 17, 2017
PubMed
Summary

Adolescent brain development involves dopamine axon growth to the prefrontal cortex, guided by DCC. Alterations in DCC impact cognitive abilities and are linked to psychiatric conditions, highlighting the Netrin-1 system as a therapeutic target.

Keywords:
DCCNetringuidance cuesmicroRNAprefrontal cortexstimulant drugs

More Related Videos

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.5K
Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

26.6K

Related Experiment Videos

Last Updated: Feb 20, 2026

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

2.8K
Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.5K
Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

26.6K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Psychiatry

Background:

  • Adolescence is a critical period for prefrontal cortex maturation, involving complex dopamine pathway development.
  • Dopamine axon growth from the striatum to the prefrontal cortex is a unique long-distance axonal projection occurring during this period.
  • The Netrin-1 guidance cue receptor DCC (deleted in colorectal cancer) plays a crucial role in coordinating this axonal growth and intrinsic cortical development.

Purpose of the Study:

  • To investigate the role of DCC in adolescent prefrontal cortex development and its implications for cognitive function.
  • To explore how adolescent stimulant drug exposure affects DCC expression and subsequent prefrontal cortex maturation.
  • To examine the link between DCC variations, microRNA regulation, and susceptibility to psychiatric disorders.

Main Methods:

  • Analysis of DCC expression in dopamine neurons during adolescent development.
  • Investigating the impact of stimulant exposure on DCC and prefrontal cortex maturation.
  • Correlating DCC gene variations and microRNA profiles with prefrontal cortex dysfunction in psychiatric conditions.

Main Results:

  • Adolescent stimulant drugs alter DCC in dopamine neurons, impacting prefrontal cortex maturation and cognitive abilities.
  • Variations in DCC expression are associated with psychiatric conditions characterized by prefrontal cortex dysfunction.
  • MicroRNA regulation of DCC is identified as a potential determinant of adolescent vulnerability or resilience.

Conclusions:

  • The Netrin-1/DCC system is a key regulator of adolescent prefrontal cortex development and cognitive function.
  • Dysregulation of DCC during adolescence, influenced by environmental factors like drug exposure, contributes to psychiatric vulnerability.
  • Targeting the Netrin-1 system offers a promising therapeutic strategy for early intervention in prefrontal cortex-related disorders.