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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
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The behavior of elastoplastic materials under bending stresses, particularly in structural members with rectangular cross-sections, is crucial for predicting material responses and understanding failure modes. Initially, when a bending moment is applied, the stress distribution across the section follows Hooke's Law and is linear and elastic. This distribution means the stress increases from the neutral axis to the maximum at the outer fibers, up to the elastic limit.
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[Ehlers-Danlos syndromes].

D-P Germain1

  • 1Service de génétique médicale, UFR des sciences de la santé Simon-Veil, université de Versailles-Saint-Quentin-en-Yvelines, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny, France.

Annales De Dermatologie Et De Venereologie
|October 17, 2017
PubMed
Summary
This summary is machine-generated.

Ehlers-Danlos syndromes (EDS) are inherited connective tissue disorders with varied symptoms. Early diagnosis and multidisciplinary care are crucial for managing these complex, potentially disabling, and sometimes life-threatening conditions.

Keywords:
Connective tissueEhlers-DanlosGenetic diseasesHyperlaxité articulaireHyperélasticité cutanéeJoint hypermobilityMaladies génétiquesMaladies métaboliquesMatrice extracellulaireMetabolic diseasesProtéoglycansSkin fragilitySkin hyperextensibilitySyndromes d’Ehlers-DanlosTissu conjonctif

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Area of Science:

  • Genetics
  • Connective Tissue Diseases
  • Molecular Biology

Background:

  • Ehlers-Danlos syndromes (EDS) are a group of inherited connective tissue disorders.
  • Common features include skin hyperextensibility, joint hypermobility, and fragile skin with delayed healing.
  • EDS are complex, multisystem diseases with varying severity, potential for disability, and life-threatening complications like vascular issues.

Purpose of the Study:

  • To present the current understanding of Ehlers-Danlos syndromes.
  • To highlight the heterogeneity and evolving classification of EDS.
  • To emphasize the importance of early diagnosis and specialized care.

Main Methods:

  • Review of current knowledge on EDS.
  • Discussion of historical and recent classifications.
  • Emphasis on molecular genetic techniques in elucidating EDS.

Main Results:

  • EDS are characterized by diverse clinical manifestations and genetic causes.
  • Classifications have evolved from 6 subtypes to include numerous variants.
  • Many EDS types are metabolic diseases linked to enzymatic defects.

Conclusions:

  • No curative treatment exists for EDS, but early diagnosis aids management and complication prevention.
  • Multidisciplinary teams in specialized centers are essential for patient care.
  • Ongoing research using molecular genetics continues to advance understanding of EDS.