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Spotlight on reticular pseudodrusen.

Alessandro Rabiolo¹, Riccardo Sacconi^1,2, Maria Vittoria Cicinelli¹

¹Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan.

Clinical Ophthalmology (Auckland, N.Z.)

|October 17, 2017

Summary

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Reticular pseudodrusen (RPD) are distinct extracellular deposits linked to severe age-related macular degeneration (AMD). Early identification using multiple imaging techniques is crucial for managing this AMD subtype.

Area of Science:

Ophthalmology
Retinal Diseases
Macular Degeneration

Background:

Age-related macular degeneration (AMD) is a primary cause of vision loss in individuals over 50.
Drusen, extracellular deposits in Bruch's membrane, are characteristic of AMD.
Reticular pseudodrusen (RPD) represent a distinct phenotype of AMD, differing in location and association with advanced disease stages.

Purpose of the Study:

To provide a comprehensive overview of reticular pseudodrusen (RPD).
To discuss the history, epidemiology, histology, and imaging of RPD.
To review functional tests, natural history, and therapeutic strategies for RPD.

Main Methods:

This is a narrative review.
Information was gathered on RPD, encompassing their definition, clinical presentation, and diagnostic challenges.

Keywords:

age-related macular degeneration choroidal neovascularization geographic atrophy reticular drusen reticular macular degeneration reticular macular disease reticular pseudodrusen subretinal drusenoid deposit

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The review synthesizes existing literature on RPD and their implications in AMD.

Main Results:

RPD are located in the subretinal space, distinguishing them from typical drusen.
RPD are strongly associated with late AMD, including geographic atrophy and specific types of choroidal neovascularization.
Accurate RPD identification requires at least two different imaging modalities due to challenges in fundus examination.

Conclusions:

Reticular pseudodrusen (RPD) are an important subtype of age-related macular degeneration (AMD).
RPD identification and understanding are critical for predicting disease progression and guiding treatment.
Further research into RPD pathogenesis and targeted therapies is warranted.